Toll-like receptor 4-mediated inflammation triggered by extracellular IFI16 is enhanced by lipopolysaccharide binding

Damage-associated molecular patterns (DAMPs) are endogenous molecules activating the immune system upon release from injured cells. Here we show that the IFI16 protein, once freely released in the extracellular milieu of chronically inflamed tissues, can function as a DAMP either alone or upon bindi...

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Dettagli Bibliografici
Pubblicato in:PLoS Pathog
Autori principali: Iannucci, Andrea, Caneparo, Valeria, Raviola, Stefano, Debernardi, Isacco, Colangelo, Donato, Miggiano, Riccardo, Griffante, Gloria, Landolfo, Santo, Gariglio, Marisa, De Andrea, Marco
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7505474/
https://ncbi.nlm.nih.gov/pubmed/32903274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008811
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