Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein

BACKGROUND: α-Synuclein (aSyn) aggregation is thought to play a central role in neurodegenerative disorders termed synucleinopathies, including Parkinson’s disease (PD). Mouse aSyn contains a threonine residue at position 53 that mimics the human familial PD substitution A53T, yet in contrast to A53...

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Pubblicato in:Mol Neurodegener
Autori principali: Landeck, Natalie, Strathearn, Katherine E., Ysselstein, Daniel, Buck, Kerstin, Dutta, Sayan, Banerjee, Siddhartha, Lv, Zhengjian, Hulleman, John D., Hindupur, Jagadish, Lin, Li-Kai, Padalkar, Sonal, Stanciu, Lia A., Lyubchenko, Yuri L., Kirik, Deniz, Rochet, Jean-Christophe
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7487555/
https://ncbi.nlm.nih.gov/pubmed/32900375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-020-00380-w
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