A Conserved Proline Hinge Mediates Helix Dynamics and Activation of Rhodopsin

Despite high-resolution crystal structures of both inactive and active G protein-coupled receptors (GPCRs), it is still not known how ligands trigger the large structural change on the intracellular side of the receptor since the conformational changes that occur within the extracellular ligand-bind...

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Udgivet i:Structure
Main Authors: Pope, Andreyah L., Sanchez-Reyes, Omar B., South, Kieron, Zaitseva, Ekaterina, Ziliox, Martine, Vogel, Reiner, Reeves, Philip J., Smith, Steven O.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484155/
https://ncbi.nlm.nih.gov/pubmed/32470317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2020.05.004
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