Highly conserved tyrosine stabilizes the active state of rhodopsin

Light-induced isomerization of the 11-cis-retinal chromophore in the visual pigment rhodopsin triggers displacement of the second extracellular loop (EL2) and motion of transmembrane helices H5, H6, and H7 leading to the active intermediate metarhodopsin II (Meta II). We describe solid-state NMR mea...

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Detalhes bibliográficos
Main Authors: Goncalves, Joseph A., South, Kieron, Ahuja, Shivani, Zaitseva, Ekaterina, Opefi, Chikwado A., Eilers, Markus, Vogel, Reiner, Reeves, Philip J., Smith, Steven O.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993422/
https://ncbi.nlm.nih.gov/pubmed/21041664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009405107
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