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Amino acid conservation and interactions in rhodopsin: Probing receptor activation by NMR spectroscopy
Rhodopsin is a classical two-state G protein-coupled receptor (GPCR). In the dark, its 11-cis retinal chromophore serves as an inverse agonist to lock the receptor in an inactive state. Retinal-protein and protein-protein interactions have evolved to reduce the basal activity of the receptor in orde...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3965625/ https://ncbi.nlm.nih.gov/pubmed/24183693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbabio.2013.10.007 |
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