KRAS Ubiquitination at Lysine 104 Retains Exchange Factor Regulation by Dynamically Modulating the Conformation of the Interface

RAS proteins function as highly regulated molecular switches that control cellular growth. In addition to regulatory proteins, RAS undergoes a number of posttranslational modifications (PTMs) that regulate its activity. Lysine 104, a hot spot for multiple PTMs, is a highly conserved residue that for...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:iScience
Main Authors: Yin, Guowei, Zhang, Jerry, Nair, Vinay, Truong, Vinh, Chaia, Angelo, Petela, Johnny, Harrison, Joseph, Gorfe, Alemayehu A., Campbell, Sharon L.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7479270/
https://ncbi.nlm.nih.gov/pubmed/32882514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101448
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki