KRAS Ubiquitination at Lysine 104 Retains Exchange Factor Regulation by Dynamically Modulating the Conformation of the Interface

RAS proteins function as highly regulated molecular switches that control cellular growth. In addition to regulatory proteins, RAS undergoes a number of posttranslational modifications (PTMs) that regulate its activity. Lysine 104, a hot spot for multiple PTMs, is a highly conserved residue that for...

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Pubblicato in:iScience
Autori principali: Yin, Guowei, Zhang, Jerry, Nair, Vinay, Truong, Vinh, Chaia, Angelo, Petela, Johnny, Harrison, Joseph, Gorfe, Alemayehu A., Campbell, Sharon L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7479270/
https://ncbi.nlm.nih.gov/pubmed/32882514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101448
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