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A KRAS GTPase K104Q Mutant Retains Downstream Signaling by Offsetting Defects in Regulation
The KRAS GTPase plays a critical role in the control of cellular growth. The activity of KRAS is regulated by guanine nucleotide exchange factors (GEFs), GTPase-activating proteins (GAPs), and also post-translational modification. Lysine 104 in KRAS can be modified by ubiquitylation and acetylation,...
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| Publicat a: | J Biol Chem |
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| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5377764/ https://ncbi.nlm.nih.gov/pubmed/28154176 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.762435 |
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