A KRAS GTPase K104Q Mutant Retains Downstream Signaling by Offsetting Defects in Regulation

The KRAS GTPase plays a critical role in the control of cellular growth. The activity of KRAS is regulated by guanine nucleotide exchange factors (GEFs), GTPase-activating proteins (GAPs), and also post-translational modification. Lysine 104 in KRAS can be modified by ubiquitylation and acetylation,...

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Vydáno v:J Biol Chem
Hlavní autoři: Yin, Guowei, Kistler, Samantha, George, Samuel D., Kuhlmann, Nora, Garvey, Leslie, Huynh, Minh, Bagni, Rachel K., Lammers, Michael, Der, Channing J., Campbell, Sharon L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377764/
https://ncbi.nlm.nih.gov/pubmed/28154176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.762435
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