KRAS Ubiquitination at Lysine 104 Retains Exchange Factor Regulation by Dynamically Modulating the Conformation of the Interface

RAS proteins function as highly regulated molecular switches that control cellular growth. In addition to regulatory proteins, RAS undergoes a number of posttranslational modifications (PTMs) that regulate its activity. Lysine 104, a hot spot for multiple PTMs, is a highly conserved residue that for...

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Publicado no:iScience
Main Authors: Yin, Guowei, Zhang, Jerry, Nair, Vinay, Truong, Vinh, Chaia, Angelo, Petela, Johnny, Harrison, Joseph, Gorfe, Alemayehu A., Campbell, Sharon L.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7479270/
https://ncbi.nlm.nih.gov/pubmed/32882514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101448
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