Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler

Virtually all aspects of cell biology are regulated by a ubiquitin code where distinct ubiquitin chain architectures guide the binding events and itineraries of modified substrates. Various combinations of E2 and E3 enzymes accomplish chain formation by forging isopeptide bonds between the C-terminu...

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Udgivet i:Nat Chem Biol
Main Authors: Liwocha, Joanna, Krist, David T., van der Heden van Noort, Gerbrand J., Hansen, Fynn M., Truong, Vinh H., Karayel, Ozge, Purser, Nicholas, Houston, Daniel, Burton, Nicole, Bostock, Mark J., Sattler, Michael, Mann, Matthias, Harrison, Joseph S., Kleiger, Gary, Ovaa, Huib, Schulman, Brenda A.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904580/
https://ncbi.nlm.nih.gov/pubmed/33288957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-00696-0
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