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Synthesis of Poly-Ubiquitin Chains Using a Bifunctional Ubiquitin Monomer

[Image: see text] An optimized large scale and highly reproducible route to orthogonally protected γ-thiolysine is reported. Its utility in the synthesis of bifunctional ubiquitin monomers is demonstrated. These ubiquitin synthons are employed in polymerization reactions giving access to synthetic p...

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Detalhes bibliográficos
Publicado no:Org Lett
Main Authors: van der Heden van Noort, Gerbrand J., Kooij, Raymond, Elliott, Paul R., Komander, David, Ovaa, Huib
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5735377/
https://ncbi.nlm.nih.gov/pubmed/29172548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.7b03085
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