Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease

Deubiquitinating enzymes (DUBs) recognize and cleave linkage-specific polyubiquitin (polyUb) chains, but mechanisms underlying specificity remain elusive in many cases. The severe acute respiratory syndrome (SARS) coronavirus papain-like protease (PLpro) is a DUB that cleaves ISG15, a two-domain Ub-...

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Pubblicato in:Mol Cell
Autori principali: Békés, Miklós, van der Heden van Noort, Gerbrand J., Ekkebus, Reggy, Ovaa, Huib, Huang, Tony T., Lima, Christopher D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier Inc. 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4875570/
https://ncbi.nlm.nih.gov/pubmed/27203180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.04.016
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