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Dimeric small molecule agonists of EphA2 receptor inhibit glioblastoma cell growth
EphA2 receptor kinase could become a novel target for anti-glioblastoma treatment. Doxazosin previously identified acts like the endogenous ligand of EphA2 and induces cell apoptosis. Through lead structure modification a derivative of Doxazosin possessing unique dimeric structure showed an improvem...
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| Publicat a: | Bioorg Med Chem |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7446891/ https://ncbi.nlm.nih.gov/pubmed/32828423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2020.115656 |
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