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A quantitative LC-MS/MS method for determination of a small molecule agonist of EphA2 in mouse plasma and brain tissue

Compound 27 [1, 12-bis(4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)dodecane-1,12-dione ] is a novel small molecule agonist of EphA2 receptor Tyrosine Kinase. It showed much improved activity for the activation of EphA2 receptor compared to the parental compound Doxazosin. To support furth...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biomed Chromatogr
Prif Awduron: Zhong, Bo, Li, Yaxin, Idippily, Nethrie, Petty, Aaron, Su, Bin, Wang, Bingcheng
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416057/
https://ncbi.nlm.nih.gov/pubmed/30548501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bmc.4461
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