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A quantitative LC-MS/MS method for determination of a small molecule agonist of EphA2 in mouse plasma and brain tissue

Compound 27 [1, 12-bis(4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)dodecane-1,12-dione ] is a novel small molecule agonist of EphA2 receptor Tyrosine Kinase. It showed much improved activity for the activation of EphA2 receptor compared to the parental compound Doxazosin. To support furth...

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Detalhes bibliográficos
Publicado no:Biomed Chromatogr
Main Authors: Zhong, Bo, Li, Yaxin, Idippily, Nethrie, Petty, Aaron, Su, Bin, Wang, Bingcheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416057/
https://ncbi.nlm.nih.gov/pubmed/30548501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bmc.4461
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