A Small Molecule Agonist of EphA2 Receptor Tyrosine Kinase Inhibits Tumor Cell Migration In Vitro and Prostate Cancer Metastasis In Vivo

During tumor progression, EphA2 receptor can gain ligand-independent pro-oncogenic functions due to Akt activation and reduced ephrin-A ligand engagement. The effects can be reversed by ligand stimulation, which triggers the intrinsic tumor suppressive signaling pathways of EphA2 including inhibitio...

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Autors principals: Petty, Aaron, Myshkin, Eugene, Qin, Haina, Guo, Hong, Miao, Hui, Tochtrop, Gregory P., Hsieh, Jer-Tsong, Page, Phillip, Liu, Lili, Lindner, Daniel J., Acharya, Chayan, MacKerell, Alexander D., Ficker, Eckhard, Song, Jianxing, Wang, Bingcheng
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419725/
https://ncbi.nlm.nih.gov/pubmed/22916121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042120
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