EphA2 Receptor Unliganded Dimers Suppress EphA2 Pro-tumorigenic Signaling

The EphA2 receptor tyrosine kinase promotes cell migration and cancer malignancy through a ligand- and kinase-independent distinctive mechanism that has been linked to high Ser-897 phosphorylation and low tyrosine phosphorylation. Here, we demonstrate that EphA2 forms dimers in the plasma membrane o...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Singh, Deo R., Ahmed, Fozia, King, Christopher, Gupta, Nisha, Salotto, Matt, Pasquale, Elena B., Hristova, Kalina
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646390/
https://ncbi.nlm.nih.gov/pubmed/26363067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.676866
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