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A Small Peptide Promotes EphA2 Kinase-Dependent Signaling by Stabilizing EphA2 Dimers

BACKGROUND: The EphA2 receptor tyrosine kinase is known to promote cancer cell malignancy in the absence of activation by ephrin ligands. This behavior depends on high EphA2 phosphorylation on Ser897 and low tyrosine phosphorylation, resulting in increased cell migration and invasiveness. We have pr...

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Publicat a:Biochim Biophys Acta
Autors principals: Singh, Deo R., Pasquale, Elena B., Hristova, Kalina
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4950921/
https://ncbi.nlm.nih.gov/pubmed/27281300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2016.06.004
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