Unliganded EphA3 dimerization promoted by the SAM domain

The erythropoietin-producing hepatocellular carcinoma A3 (EphA3) receptor tyrosine kinase (RTK) regulates morphogenesis during development and is overexpressed and mutated in a variety of cancers. EphA3 activation is believed to follow a ‘seeding mechanism’ model, in which ligand binding to the mono...

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Veröffentlicht in:Biochem J
Hauptverfasser: Singh, Deo R., Cao, QingQing, King, Christopher, Salotto, Matt, Ahmed, Fozia, Zhou, Xiang Yang, Pasquale, Elena B., Hristova, Kalina
Format: Artigo
Sprache:Inglês
Veröffentlicht: Portland Press Ltd. 2015
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4692061/
https://ncbi.nlm.nih.gov/pubmed/26232493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20150433
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