A cancer mutation promotes EphA4 oligomerization and signaling by altering the conformation of the SAM domain

The Eph receptor tyrosine kinases and their ephrin ligands regulate many physiological and pathological processes. EphA4 plays important roles in nervous system development and adult homeostasis, while aberrant EphA4 signaling has been implicated in neurodegeneration. EphA4 may also affect cancer ma...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Light, Taylor P., Gomez-Soler, Maricel, Wang, Zichen, Karl, Kelly, Zapata-Mercado, Elmer, Gehring, Marina P., Lechtenberg, Bernhard C., Pogorelov, Taras V., Hristova, Kalina, Pasquale, Elena B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8260879/
https://ncbi.nlm.nih.gov/pubmed/34139238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100876
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