Small-Molecule HSP27 Inhibitor Abolishes Androgen Receptors in Glioblastoma

Androgen receptor (AR) contributes to the progression of glioblastoma (GBM), and antiandrogen agents have the potential to be used for the treatment of GBM. However, AR mutation commonly happens in GBM, which makes the antiandrogen agents less effective. Heat shock 27 kDa protein (HSP27) is a well-d...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Med Chem
Prif Awduron: Li, Yaxin, Orahoske, Cody M., Geldenhuys, Werner J., Bhattarai, Asmita, Sabbagh, Abboud, Bobba, Viharika, Salem, Fatma M., Zhang, Wenjing, Shukla, Girish C., Lathia, Justin D., Wang, Bingcheng, Su, Bin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284899/
https://ncbi.nlm.nih.gov/pubmed/33523674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c01537
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