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Lead optimization of selective tubulin inhibitors as anti-trypanosomal agents
Previously synthesized tubulin inhibitors showed promising in vitro selectivity and activity against Human African Trypanosomiasis. Current aim is to improve the ligand efficiency and reduce overall hydrophobicity of the compounds, by lead optimization. Via combinatorial chemistry, 60 new analogs we...
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| Publicado no: | Bioorg Med Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6531046/ https://ncbi.nlm.nih.gov/pubmed/30833159 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2019.02.049 |
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