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Lead optimization of selective tubulin inhibitors as anti-trypanosomal agents
Previously synthesized tubulin inhibitors showed promising in vitro selectivity and activity against Human African Trypanosomiasis. Current aim is to improve the ligand efficiency and reduce overall hydrophobicity of the compounds, by lead optimization. Via combinatorial chemistry, 60 new analogs we...
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| Vydáno v: | Bioorg Med Chem |
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| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6531046/ https://ncbi.nlm.nih.gov/pubmed/30833159 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2019.02.049 |
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