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Synthesis and biological evaluation of selective tubulin inhibitors as anti-trypanosomal agents

African trypanosomiasis is still a threat to human health due to the severe side-effects of current drugs. We identified selective tubulin inhibitors that showed the promise to the treatment of this disease, which was based on the tubulin protein structural difference between mammalian and trypanoso...

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Podrobná bibliografie
Vydáno v:Bioorg Med Chem
Hlavní autoři: Bobba, Viharika, Nanavaty, Vishal, Idippily, Nethrie D., Zhao, Anran, Li, Bibo, Su, Bin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509440/
https://ncbi.nlm.nih.gov/pubmed/28428042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.04.009
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