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Synthesis and biological evaluation of selective tubulin inhibitors as anti-trypanosomal agents

African trypanosomiasis is still a threat to human health due to the severe side-effects of current drugs. We identified selective tubulin inhibitors that showed the promise to the treatment of this disease, which was based on the tubulin protein structural difference between mammalian and trypanoso...

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Detalles Bibliográficos
Publicado en:Bioorg Med Chem
Main Authors: Bobba, Viharika, Nanavaty, Vishal, Idippily, Nethrie D., Zhao, Anran, Li, Bibo, Su, Bin
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509440/
https://ncbi.nlm.nih.gov/pubmed/28428042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.04.009
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