Targeting cPLA(2) derived lipid hydroperoxides as a potential intervention for sarcopenia

Defects in neuromuscular innervation contribute significantly to the age-related decline in muscle mass and function (sarcopenia). Our previous studies demonstrated that denervation induces muscle mitochondrial hydroperoxide production (H(2)O(2) and lipid hydroperoxides (LOOHs)). Here we define the...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Pharaoh, Gavin, Brown, Jacob L., Sataranatarajan, Kavithalakshmi, Kneis, Parker, Bian, Jan, Ranjit, Rojina, Hadad, Niran, Georgescu, Constantin, Rabinovitch, Peter, Ran, Qitao, Wren, Jonathan D., Freeman, Willard, Kinter, Michael, Richardson, Arlan, Van Remmen, Holly
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7435184/
https://ncbi.nlm.nih.gov/pubmed/32811851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-70792-7
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