Ablation of the mitochondrial complex IV assembly protein Surf1 leads to increased expression of the UPR(MT) and increased resistance to oxidative stress in primary cultures of fibroblasts

Mice deficient in the electron transport chain (ETC) complex IV assembly protein SURF1 have reduced assembly and activity of cytochrome c oxidase that is associated with an upregulation of components of the mitochondrial unfolded protein response (UPR(MT)) and increased mitochondrial number. We hypo...

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Bibliographic Details
Published in:Redox Biol
Main Authors: Pharaoh, Gavin, Pulliam, Daniel, Hill, Shauna, Sataranatarajan, Kavithalakshmi, Van Remmen, Holly
Format: Artigo
Language:Inglês
Published: Elsevier 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878459/
https://ncbi.nlm.nih.gov/pubmed/27208630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2016.05.001
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