Restoration of Sarcoplasmic Reticulum Ca(2+) ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice

Sarcopenia has a significant negative impact on healthspan in the elderly and effective pharmacologic interventions remain elusive. We have previously demonstrated that sarcopenia is associated with reduced activity of the sarcoplasmic reticulum Ca(2+) ATPase (SERCA) pump. We asked whether restoring...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Qaisar, Rizwan, Pharaoh, Gavin, Bhaskaran, Shylesh, Xu, Hongyang, Ranjit, Rojina, Bian, Jan, Ahn, Bumsoo, Georgescu, Constantin, Wren, Jonathan D., Van Remmen, Holly
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7792969/
https://ncbi.nlm.nih.gov/pubmed/33375170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22010037
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