The NSD2/WHSC1/MMSET methyltransferase prevents cellular senescence‐associated epigenomic remodeling

Senescent cells may possess the intrinsic programs of metabolic and epigenomic remodeling, but the molecular mechanism remains to be clarified. Using an RNAi‐based screen of chromatin regulators, we found that knockdown of the NSD2/WHSC1/MMSET methyltransferase induced cellular senescence that augme...

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Bibliografiska uppgifter
I publikationen:Aging Cell
Huvudupphovsmän: Tanaka, Hiroshi, Igata, Tomoka, Etoh, Kan, Koga, Tomoaki, Takebayashi, Shin‐ichiro, Nakao, Mitsuyoshi
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2020
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Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7433007/
https://ncbi.nlm.nih.gov/pubmed/32573059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13173
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