The NSD2/WHSC1/MMSET methyltransferase prevents cellular senescence‐associated epigenomic remodeling

Senescent cells may possess the intrinsic programs of metabolic and epigenomic remodeling, but the molecular mechanism remains to be clarified. Using an RNAi‐based screen of chromatin regulators, we found that knockdown of the NSD2/WHSC1/MMSET methyltransferase induced cellular senescence that augme...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Aging Cell
Prif Awduron: Tanaka, Hiroshi, Igata, Tomoka, Etoh, Kan, Koga, Tomoaki, Takebayashi, Shin‐ichiro, Nakao, Mitsuyoshi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2020
Pynciau:
Original Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7433007/
https://ncbi.nlm.nih.gov/pubmed/32573059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13173
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