The Histone Methyltransferase MMSET/WHSC1 Activates TWIST1 to Promote an Epithelial-Mesenchymal Transition and Invasive Properties of Prostate Cancer

Epigenetic deregulation of gene expression plays a role in the initiation and progression of prostate cancer (PCa). The histone methyltransferase MMSET/WHSC1 (Multiple Myeloma Set Domain) is overexpressed in a number of metastatic tumors, but its mechanism of action has not been defined. In this wor...

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Autors principals: Ezponda, Teresa, Popovic, Relja, Shah, Mrinal Y., Martinez-Garcia, Eva, Zheng, Yupeng, Min, Dong-Joon, Will, Christine, Neri, Antonino, Kelleher, Neil L., Yu, Jindan, Licht, Jonathan D.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3495247/
https://ncbi.nlm.nih.gov/pubmed/22797064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.297
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