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MMSET/WHSC1 enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents
MMSET/WHSC1 is a histone methyltransferase (HMT) overexpressed in t(4;14)+ multiple myeloma (MM) patients, believed to be the driving factor in the pathogenesis of this MM subtype. MMSET overexpression in MM leads to an increase in histone 3 lysine 36 dimethylation (H3K36me2), and a decrease in hist...
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| Udgivet i: | Oncogene |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6071667/ https://ncbi.nlm.nih.gov/pubmed/27109101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.116 |
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