The NSD2/WHSC1/MMSET methyltransferase prevents cellular senescence‐associated epigenomic remodeling

Senescent cells may possess the intrinsic programs of metabolic and epigenomic remodeling, but the molecular mechanism remains to be clarified. Using an RNAi‐based screen of chromatin regulators, we found that knockdown of the NSD2/WHSC1/MMSET methyltransferase induced cellular senescence that augme...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Aging Cell
Egile Nagusiak: Tanaka, Hiroshi, Igata, Tomoka, Etoh, Kan, Koga, Tomoaki, Takebayashi, Shin‐ichiro, Nakao, Mitsuyoshi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2020
Gaiak:
Original Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7433007/
https://ncbi.nlm.nih.gov/pubmed/32573059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13173
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