The NSD2/WHSC1/MMSET methyltransferase prevents cellular senescence‐associated epigenomic remodeling

Senescent cells may possess the intrinsic programs of metabolic and epigenomic remodeling, but the molecular mechanism remains to be clarified. Using an RNAi‐based screen of chromatin regulators, we found that knockdown of the NSD2/WHSC1/MMSET methyltransferase induced cellular senescence that augme...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Aging Cell
Auteurs principaux: Tanaka, Hiroshi, Igata, Tomoka, Etoh, Kan, Koga, Tomoaki, Takebayashi, Shin‐ichiro, Nakao, Mitsuyoshi
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2020
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7433007/
https://ncbi.nlm.nih.gov/pubmed/32573059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13173
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires