Identification of a peptide inhibitor for the histone methyltransferase WHSC1

WHSC1 is a histone methyltransferase that is responsible for mono- and dimethylation of lysine 36 on histone H3 and has been implicated as a driver in a variety of hematological and solid tumors. Currently, there is a complete lack of validated chemical matter for this important drug discovery targe...

Full description

Saved in:
Bibliographic Details
Published in:PLoS One
Main Authors: Morrison, Michael J., Boriack-Sjodin, P. Ann, Swinger, Kerren K., Wigle, Tim J., Sadalge, Dipti, Kuntz, Kevin W., Scott, Margaret Porter, Janzen, William P., Chesworth, Richard, Duncan, Kenneth W., Harvey, Darren M., Lampe, John W., Mitchell, Lorna H., Copeland, Robert A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5942779/
https://ncbi.nlm.nih.gov/pubmed/29742153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197082
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items