AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis

Loss of phosphatase and tensin homolog (PTEN) and activation of the PI3K/AKT signaling pathway are hallmarks of prostate cancer (PCa). However, these alterations alone are insufficient for cells to acquire metastatic traits. Here, we have shown that the histone dimethyl transferase WHSC1 critically...

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Udgivet i:J Clin Invest
Main Authors: Li, Ni, Xue, Wei, Yuan, Huairui, Dong, Baijun, Ding, Yufeng, Liu, Yongfeng, Jiang, Min, Kan, Shan, Sun, Tongyu, Ren, Jiale, Pan, Qiang, Li, Xiang, Zhang, Peiyuan, Hu, Guohong, Wang, Yan, Wang, Xiaoming, Li, Qintong, Qin, Jun
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373871/
https://ncbi.nlm.nih.gov/pubmed/28319045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI91144
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