טוען...
Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis
The histone H3K36 methyltransferase SETD2 is frequently mutated or deleted in a variety of human tumors. Nevertheless, the role of SETD2 loss in oncogenesis remains largely undefined. Here, we found that SETD2 counteracts Wnt signaling and its inactivation promotes intestinal tumorigenesis in mouse...
שמור ב:
| הוצא לאור ב: | J Clin Invest |
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| Main Authors: | , , , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Society for Clinical Investigation
2017
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5669571/ https://ncbi.nlm.nih.gov/pubmed/28825595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI94292 |
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