Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis

The histone H3K36 methyltransferase SETD2 is frequently mutated or deleted in a variety of human tumors. Nevertheless, the role of SETD2 loss in oncogenesis remains largely undefined. Here, we found that SETD2 counteracts Wnt signaling and its inactivation promotes intestinal tumorigenesis in mouse...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Yuan, Huairui, Li, Ni, Fu, Da, Ren, Jiale, Hui, Jingyi, Peng, Junjie, Liu, Yongfeng, Qiu, Tong, Jiang, Min, Pan, Qiang, Han, Ying, Wang, Xiaoming, Li, Qintong, Qin, Jun
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669571/
https://ncbi.nlm.nih.gov/pubmed/28825595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI94292
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