Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis

The histone H3K36 methyltransferase SETD2 is frequently mutated or deleted in a variety of human tumors. Nevertheless, the role of SETD2 loss in oncogenesis remains largely undefined. Here, we found that SETD2 counteracts Wnt signaling and its inactivation promotes intestinal tumorigenesis in mouse...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Yuan, Huairui, Li, Ni, Fu, Da, Ren, Jiale, Hui, Jingyi, Peng, Junjie, Liu, Yongfeng, Qiu, Tong, Jiang, Min, Pan, Qiang, Han, Ying, Wang, Xiaoming, Li, Qintong, Qin, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669571/
https://ncbi.nlm.nih.gov/pubmed/28825595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI94292
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