Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis

The histone H3K36 methyltransferase SETD2 is frequently mutated or deleted in a variety of human tumors. Nevertheless, the role of SETD2 loss in oncogenesis remains largely undefined. Here, we found that SETD2 counteracts Wnt signaling and its inactivation promotes intestinal tumorigenesis in mouse...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Clin Invest
Egile Nagusiak: Yuan, Huairui, Li, Ni, Fu, Da, Ren, Jiale, Hui, Jingyi, Peng, Junjie, Liu, Yongfeng, Qiu, Tong, Jiang, Min, Pan, Qiang, Han, Ying, Wang, Xiaoming, Li, Qintong, Qin, Jun
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2017
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669571/
https://ncbi.nlm.nih.gov/pubmed/28825595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI94292
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