AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis

Loss of phosphatase and tensin homolog (PTEN) and activation of the PI3K/AKT signaling pathway are hallmarks of prostate cancer (PCa). However, these alterations alone are insufficient for cells to acquire metastatic traits. Here, we have shown that the histone dimethyl transferase WHSC1 critically...

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Библиографические подробности
Опубликовано в: :J Clin Invest
Главные авторы: Li, Ni, Xue, Wei, Yuan, Huairui, Dong, Baijun, Ding, Yufeng, Liu, Yongfeng, Jiang, Min, Kan, Shan, Sun, Tongyu, Ren, Jiale, Pan, Qiang, Li, Xiang, Zhang, Peiyuan, Hu, Guohong, Wang, Yan, Wang, Xiaoming, Li, Qintong, Qin, Jun
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2017
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373871/
https://ncbi.nlm.nih.gov/pubmed/28319045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI91144
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