Identification of a peptide inhibitor for the histone methyltransferase WHSC1

WHSC1 is a histone methyltransferase that is responsible for mono- and dimethylation of lysine 36 on histone H3 and has been implicated as a driver in a variety of hematological and solid tumors. Currently, there is a complete lack of validated chemical matter for this important drug discovery targe...

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Veröffentlicht in:PLoS One
Hauptverfasser: Morrison, Michael J., Boriack-Sjodin, P. Ann, Swinger, Kerren K., Wigle, Tim J., Sadalge, Dipti, Kuntz, Kevin W., Scott, Margaret Porter, Janzen, William P., Chesworth, Richard, Duncan, Kenneth W., Harvey, Darren M., Lampe, John W., Mitchell, Lorna H., Copeland, Robert A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5942779/
https://ncbi.nlm.nih.gov/pubmed/29742153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197082
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