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Optimization of High-Throughput Methyltransferase Assays for the Discovery of Small Molecule Inhibitors

Methyltransferases (MTases) play diverse roles in cellular processes. Aberrant methylation levels have been implicated in many diseases, indicating the need for the identification and development of small molecule inhibitors for each MTase. Specific inhibitors can serve as probes to investigate the...

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Veröffentlicht in:ACS Comb Sci
Hauptverfasser: Dong, Guangping, Yasgar, Adam, Peterson, Darrell L., Zakharov, Alexey, Talley, Daniel, Cheng, Ken Chih-Chien, Jadhav, Ajit, Simeonov, Anton, Huang, Rong
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429283/
https://ncbi.nlm.nih.gov/pubmed/32525297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscombsci.0c00077
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