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Optimization of High-Throughput Methyltransferase Assays for the Discovery of Small Molecule Inhibitors

Methyltransferases (MTases) play diverse roles in cellular processes. Aberrant methylation levels have been implicated in many diseases, indicating the need for the identification and development of small molecule inhibitors for each MTase. Specific inhibitors can serve as probes to investigate the...

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Bibliografiska uppgifter
I publikationen:ACS Comb Sci
Huvudupphovsmän: Dong, Guangping, Yasgar, Adam, Peterson, Darrell L., Zakharov, Alexey, Talley, Daniel, Cheng, Ken Chih-Chien, Jadhav, Ajit, Simeonov, Anton, Huang, Rong
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429283/
https://ncbi.nlm.nih.gov/pubmed/32525297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscombsci.0c00077
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