Cell Lysate-Based AlphaLISA Deubiquitinase Assay Platform for Identification of Small Molecule Inhibitors

The deubiquitinases, or DUBs, are associated with various human diseases, including neurological disorders, cancer, and viral infection, making them excellent candidates for pharmacological intervention. Drug discovery campaigns against DUBs require enzymatic deubiquitination assays amenable for hig...

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Bibliographic Details
Published in:ACS Chem Biol
Main Authors: Ott, Christine A, Baljinnyam, Bolormaa, Zakharov, Alexey V., Jadhav, Ajit, Simeonov, Anton, Zhuang, Zhihao
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5947317/
https://ncbi.nlm.nih.gov/pubmed/28836754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00543
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