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A High-Throughput Assay for Small Molecule Destabilizers of the KRAS Oncoprotein
Mutations in the Ras family of small GTPases, particularly KRAS, occur at high frequencies in cancer and represent a major unmet therapeutic need due to the lack of effective targeted therapies. Past efforts directed at inhibiting the activity of the Ras oncoprotein have proved difficult. We propose...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4122376/ https://ncbi.nlm.nih.gov/pubmed/25093678 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103836 |
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