A High-Throughput Assay for Small Molecule Destabilizers of the KRAS Oncoprotein

Mutations in the Ras family of small GTPases, particularly KRAS, occur at high frequencies in cancer and represent a major unmet therapeutic need due to the lack of effective targeted therapies. Past efforts directed at inhibiting the activity of the Ras oncoprotein have proved difficult. We propose...

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Main Authors: Carver, Joseph, Dexheimer, Thomas S., Hsu, Dennis, Weng, Meng-Tzu, Smith, Jordan L., Guha, Rajarshi, Jadhav, Ajit, Simeonov, Anton, Luo, Ji
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4122376/
https://ncbi.nlm.nih.gov/pubmed/25093678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103836
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