A High-Throughput Assay for Small Molecule Destabilizers of the KRAS Oncoprotein

Mutations in the Ras family of small GTPases, particularly KRAS, occur at high frequencies in cancer and represent a major unmet therapeutic need due to the lack of effective targeted therapies. Past efforts directed at inhibiting the activity of the Ras oncoprotein have proved difficult. We propose...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Carver, Joseph, Dexheimer, Thomas S., Hsu, Dennis, Weng, Meng-Tzu, Smith, Jordan L., Guha, Rajarshi, Jadhav, Ajit, Simeonov, Anton, Luo, Ji
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4122376/
https://ncbi.nlm.nih.gov/pubmed/25093678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103836
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires