Altered 3D chromatin structure permits inversional recombination at the IgH locus

Immunoglobulin heavy chain (IgH) genes are assembled by two sequential DNA rearrangement events that are initiated by recombination activating gene products (RAG) 1 and 2. Diversity (D(H)) gene segments rearrange first, followed by variable (V(H)) gene rearrangements. Here, we provide evidence that...

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Bibliografski detalji
Izdano u:Sci Adv
Glavni autori: Qiu, Xiang, Ma, Fei, Zhao, Mingming, Cao, Yaqiang, Shipp, Lillian, Liu, Angela, Dutta, Arun, Singh, Amit, Braikia, Fatima Zohra, De, Supriyo, Wood, William H., Becker, Kevin G., Zhou, Weiqiang, Ji, Hongkai, Zhao, Keji, Atchison, Michael L., Sen, Ranjan
Format: Artigo
Jezik:Inglês
Izdano: American Association for the Advancement of Science 2020
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7428332/
https://ncbi.nlm.nih.gov/pubmed/32851160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz8850
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