Altered 3D chromatin structure permits inversional recombination at the IgH locus

Immunoglobulin heavy chain (IgH) genes are assembled by two sequential DNA rearrangement events that are initiated by recombination activating gene products (RAG) 1 and 2. Diversity (D(H)) gene segments rearrange first, followed by variable (V(H)) gene rearrangements. Here, we provide evidence that...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Qiu, Xiang, Ma, Fei, Zhao, Mingming, Cao, Yaqiang, Shipp, Lillian, Liu, Angela, Dutta, Arun, Singh, Amit, Braikia, Fatima Zohra, De, Supriyo, Wood, William H., Becker, Kevin G., Zhou, Weiqiang, Ji, Hongkai, Zhao, Keji, Atchison, Michael L., Sen, Ranjan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2020
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7428332/
https://ncbi.nlm.nih.gov/pubmed/32851160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz8850
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