Altered 3D chromatin structure permits inversional recombination at the IgH locus

Immunoglobulin heavy chain (IgH) genes are assembled by two sequential DNA rearrangement events that are initiated by recombination activating gene products (RAG) 1 and 2. Diversity (D(H)) gene segments rearrange first, followed by variable (V(H)) gene rearrangements. Here, we provide evidence that...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Qiu, Xiang, Ma, Fei, Zhao, Mingming, Cao, Yaqiang, Shipp, Lillian, Liu, Angela, Dutta, Arun, Singh, Amit, Braikia, Fatima Zohra, De, Supriyo, Wood, William H., Becker, Kevin G., Zhou, Weiqiang, Ji, Hongkai, Zhao, Keji, Atchison, Michael L., Sen, Ranjan
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7428332/
https://ncbi.nlm.nih.gov/pubmed/32851160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz8850
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