Sequential enhancer sequestration dysregulates recombination center formation at the IgH locus

Immunoglobulin heavy chain (IgH) genes are assembled by DNA rearrangements that juxtapose a variable (V(H)), a diversity (D(H)), and a joining (J(H)) gene segment. Here we report that in the absence of intergenic control region 1 (IGCR1) the intronic enhancer (Eμ) associates with the next available...

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Bibliographic Details
Published in:Mol Cell
Main Authors: Qiu, Xiang, Kumari, Gita, Gerasimova, Tatiana, Du, Hansen, Labaran, Lawal, Singh, Amit, De, Supriyo, Wood, William H., Becker, Kevin G., Zhou, Weiqiang, Ji, Hongkai, Sen, Ranjan
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003238/
https://ncbi.nlm.nih.gov/pubmed/29576529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.02.020
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