PKCλ/ι loss induces autophagy, oxidative phosphorylation, and NRF2 to promote liver cancer progression

Oxidative stress plays a critical role in liver tissue damage and in hepatocellular carcinoma (HCC) initiation and progression. However, the mechanisms that regulate autophagy and metabolic reprogramming during reactive oxygen species (ROS) generation, and how ROS promote tumorigenesis, still need t...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Kudo, Yotaro, Sugimoto, Masayuki, Arias, Esperanza, Kasashima, Hiroaki, Cordes, Thekla, Linares, Juan F., Duran, Angeles, Nakanishi, Yuki, Nakanishi, Naoko, L’Hermitte, Antoine, Campos, Alex, Senni, Nadia, Rooslid, Tarmo, Roberts, Lewis R., Maria Cuervo, Ana, Metallo, Christian M., Karin, Michael, Diaz-Meco, Maria T., Moscat, Jorge
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7423690/
https://ncbi.nlm.nih.gov/pubmed/32589943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2020.05.018
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