Increased Serine and One Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer

Increasingly effective therapies targeting the androgen receptor have paradoxically promoted the incidence of neuroendocrine prostate cancer (NEPC), the most lethal subtype of castration-resistant prostate cancer (PCa), for which there is no effective therapy. Here we report that protein kinase C (P...

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Udgivet i:Cancer Cell
Main Authors: Reina-Campos, Miguel, Linares, Juan F., Duran, Angeles, Cordes, Thekla, L’Hermitte, Antoine, Badur, Mehmet G., Bhangoo, Munveer S., Thorson, Phataraporn K., Richards, Alicia, Rooslid, Tarmo, Garcia-Olmo, Dolores C., Nam-Cha, Syongh Y., Salinas-Sanchez, Antonio S., Eng, Ken, Beltran, Himisha, Scott, David A., Metallo, Christian M., Moscat, Jorge, Diaz-Meco, Maria T.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6424636/
https://ncbi.nlm.nih.gov/pubmed/30827887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.01.018
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