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Loss of PKCλ/ι impairs Th2 establishment and allergic airway inflammation in vivo
The differentiation of T cells along different lineages is central to the control of immunity. Here we have used a conditional gene knockout system to delete PKCλ/ι selectively in activated T cells. With this system we have demonstrated that PKCλ/ι is necessary for T-helper cell (Th2) cytokine produ...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2633554/ https://ncbi.nlm.nih.gov/pubmed/19144923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805907106 |
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