Loss of Podocyte aPKCλ/ι Causes Polarity Defects and Nephrotic Syndrome

Atypical protein kinase C (aPKC) is a central component of the evolutionarily conserved Par3-Par6-aPKC complex, one of the fundamental regulators of cell polarity. We recently demonstrated that these proteins interact with Neph-nephrin molecules at the slit diaphragm of the glomerular filtration bar...

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Bibliografski detalji
Glavni autori: Huber, Tobias B., Hartleben, Björn, Winkelmann, Kirstin, Schneider, Lisa, Becker, Jan U., Leitges, Michael, Walz, Gerd, Haller, Hermann, Schiffer, Mario
Format: Artigo
Jezik:Inglês
Izdano: American Society of Nephrology 2009
Teme:
Basic Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663834/
https://ncbi.nlm.nih.gov/pubmed/19279126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2008080871
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